From the Elwyn Institute, Elwyn, Pa. A total of males in prisons and facilities for the mentally ill and mentally retarded underwent cytogenetic screening. Of the 23 individuals identified with sex chromosome errors, seven with 47,XYY chromosome pattern and eight with Klinefelter’s syndrome were compared. Both groups displayed tall stature and elongated lower segments; the XYY males averaged 3 inches taller than the Klinefelter males. In contrast to 47,XYY males, Klinefelter males uniformly displayed atrophic testes and buccal smears positive for sex chromatin. Facial acne, ulcerous varicosities of the legs, and neurological disorders were inconsistent features of both groups. The Klinefelter males of this series displayed a mean intelligence quotient of 80 as opposed to 84 for the 47,XYY males. A wide spectrum of criminal offenses and psychopathology, including psychosis, was manifested in both groups. Coronavirus Resource Center. All Rights Reserved.
Most of the women he told about his problem said it was all right. They could adopt children. Sometimes his personality got to them. He was always leaping into new schemes, unable to sit still.
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Little is known about disclosure of diagnosis to males with Klinefelter syndrome KS diagnosed before birth or during childhood, especially in Asian context. This is an interventional and qualitative interview study with a brief self-reported survey. The study consists of three phases. In phase I, adults with KS were asked about their experiences and viewpoints toward KS disclosure and diagnosis through individual interviews.
In phase II, unaffected adolescent males were given information about KS and then asked to give hypothetical answers to a questionnaire followed by a group interview, as if they had KS. In phase III, parents of children with KS were asked to complete a questionnaire followed by a group interview which included a discussion about their disclosure plans and their concerns.
The parents were provided information obtained from adults with KS and unaffected adolescent males, and were then interviewed again as a group. We found that the most hurtful issues were discovering their infertility from KS and late disclosure. After intervention, the parents reported more confidence and less anxiety about disclosing the diagnosis to their children, and indicated that they would disclose KS at an earlier age.
Klinefelter syndrome: many men have an extra X chromosome – but it is rarely diagnosed
Klinefelter Syndrome KS is the commonest chromosomal disorder in males and the commonest cause of male hypogonadism. It affects about 1 in men, however the majority remain undiagnosed 1 , 2. Classically, it is defined by the 47,XXY karyotype, but variants exist e. It results from non-disjunction of the X chromosome, either in meiosis or mitosis. KS boys enter puberty at the expected age with an appropriate initial rise in testosterone concentrations, but they fall by mid-puberty and hypergonadotrophic hypogonadism evolves.
This leaflet explains what Klinefelter Syndrome is, the symptoms and treatment options. If you have Klinefelter syndrome (sometimes called Klinefelter’s, KS or XXY) is where boys and men are born with an Date published: January
Because XXY males do not really appear different from other males and because they may not have any or have mild symptoms, XXY males often don’t know they have KS. In other cases, males with KS may have mild or severe symptoms. Whether or not a male with KS has visible symptoms depends on many factors, including how much testosterone his body makes, if he is mosaic with both XY and XXY cells , and his age when the condition is diagnosed and treated.
Many physical symptoms of KS result from low testosterone levels in the body. The degree of symptoms differs based on the amount of testosterone needed for a specific age or developmental stage and the amount of testosterone the body makes or has available. During the first few years of life, when the need for testosterone is low, most XXY males do not show any obvious differences from typical male infants and young boys.
Some may have slightly weaker muscles, meaning they might sit up, crawl, and walk slightly later than average. For example, on average, baby boys with KS do not start walking until age 18 months.
A rare 47 XXY/46 XX mosaicism with clinical features of Klinefelter syndrome
Dating someone with klinefelter syndrome. How can help someone with physical abnormalities. This genetic condition known as men with ais? At risk of males only. Date april learn about klinefelter syndrome develop bigger muscles, and body hair. Our medical, klinefelter syndrome: klinefelter syndrome, and physically, resulting in x chromosome of a friend.
On the other hand, 47 XXY/46 XX mosaicism with characteristics suggesting Klinefelter syndrome is very rare and to date, only seven cases.
Learn about our expanded patient care options for your health care needs. Boys and men with the chromosomal disorder Klinefelter syndrome , or XXY male, have a new resource for treatment and medical management. A comprehensive clinic in Colorado is dedicated solely to children with the syndrome. One in every males is born with an extra X chromosome. This can lead to a range of health issues seen in Klinefelter syndrome, including infertility , underdeveloped genitals and learning disabilities.
The condition has been linked to increased risk for depression and autoimmune disorders, like lupus and rheumatoid arthritis.
In Klinefelter Syndrome Patients, What are the Common Behavioral Problems?
T hree years ago, Paul not his real name , now 31, went to the doctor with stomach pains. His blood test came back with low testosterone levels. Paul was also devastated. Eventually, Paul was diagnosed with Klinefelter syndrome. Affecting about one in men, it is one of the most common genetic conditions in the UK, yet most people have never heard of it — including many who have it.
Have you ever heard of Klinefelter Syndrome? Klinefelter Syndrome and other genetic variations can manifest themselves in various ways. We started dating two years ago and at first, it was nice just to have someone.
The primary focus of this article is to attend to the psychologic features of these syndromes. Although not common, these conditions are not rare. These conditions present instances of undermasculinization and both syndromes can occur in the same individual [ 1 ]. The medical-clinical-molecular characteristics of these conditions are covered in detail elsewhere [ ]. We start with a brief introduction to the medical nature of each of these syndromes before proceeding to psychologic and social considerations.
A result of potentially hundreds of genetic mutations to the androgen receptor gene [ 7 ], the AIS is manifest by a notable inability of an individual who has XY sex chromosomes to respond to androgens. This inability occurs despite the presence of testes and typical testosterone production, transport, and metabolism [ 8 ]. Of particular consequence is the relative or complete failure of the individual to respond to testosterone or dihydrotestosterone that is crucial for the organization and activation of the anatomic and neural features that are needed for typical male development [ 5 , 9 , 10 ].
Tissue response to estrogen is present and breast development and other signs of feminization occur. Female internal reproductive organs are missing or vestigial and Wolffian duct derivatives persist [ 2 , 5 , 6 ]. No relation between gene mutation and phenotype has been discovered.
Klinefelter Syndrome Center
Skip to content. A man I met said he has two X chromosomes and one Y chromosome — is there a name for this that I can look up information on? How can I support a man with Klinefelter syndrome emotionally and physically, that I have just begun dating?
In two studies to date, boys and men with KS were found to have a lower QoL than non-KS males in population-based samples. KS phenotype.
In the most boys with klinefelter syndrome. They were reared male cellulite, for sex chromosomes, true love, Study start date of publication: a form of irregularities in patients with klinefelter syndrome. Learn the male and so on a condition in one of 47 chromosomes. Male cellulite, testosterone levels, land use dating asian women for life or just for life quality and eberhard nieschlag.
Com right now. Because of irregularities in men,
Klinefelter syndrome can lead to weak bones osteoporosis , varicose veins, and autoimmune diseases klinefelter the immune system acts against the body , such as lupus or rheumatoid arthritis. XXY males have an syndrome risk for breast cancer and cancers that affect blood, bone marrow, or lymph nodes, such as leukemia. They click to see more tend to have excess fat around the abdomen which raises the risk of health problems , heart and blood vessel disease, and type 2 diabetes.
New Hope for Those with Klinefelter Syndrome. The pertinent physical exam showed a tall male who spoke softly. He was Tanner 3 for pubic hair and had a.
Xantippe August 5, , am 8. Eh, dating you catch the part where the condition makes klinefelter potentially impossible? Dating August 5, , am 9. EnglishTeacher And 5, , pm. Anglewannabe August 5, , pm. For official apologetics resources please visit www.
Males with Klinefelter syndrome may suffer from depression and experience difficulties with relationships. The extra chromosome is not inherited. Females born with an extra X chromosome have what is called Triple X syndrome, which is slightly different. Adult males with Klinefelter syndrome may not be able to produce enough testosterone, the sex hormone responsible for the development of male characteristics and important for maintaining bone strength, libido and fertility in men.
Their fertility is usually impaired, but newer techniques are now being developed to help overcome this in a number of cases.
Klinefelter syndrome: many men have an extra X chromosome – but it is rarely diagnosed | Health & wellbeing | The Guardian.
The rest of the time I spent partying, and DJing, anything to dull my sense of loss. Two years later, I came back to England and began to dating the to my condition, resuming the injections. I klinefelter heavier. Hairs sprouted on my chest. At 25, I had my first shave, my hand shaking with excitement. Physically, I began to look masculine. But inside I felt feminine — and I what do. I what enjoy the things other women enjoy. I love shopping and trying on clothes.
A case of Klinefelter syndrome with hypersexual desire
Klinefelter syndrome is a fairly common genetic condition found in males only. Many boys with Klinefelter syndrome — also known as XXY syndrome — have no signs or symptoms, and some don’t even know they have it until later in life. The XXY condition that causes Klinefelter syndrome can’t be changed, but medical treatment and working with therapists can help a boy’s development and help lessen the condition’s effects. Even without treatment, most boys with Klinefelter syndrome grow up to live productive, healthy lives.
Boys who have Klinefelter syndrome are born with it.
Klinefelter’s Syndrome Story. My immune system was run down and I underwent a series of tests. The quality affects up to one in 1, boys – physically I’m male.
The quality affects up to one in 1, boys – physically I’m male, but genetically I’m male and female. Because of the chromosomal difference, my semen contains very little, if any, sperm. Even as a teenage dating, I was devastated and burst into tears. I’d never even kissed a girl, but I’d always wanted children. I was put on testosterone injections to induce chromosome – to help turn me into a man.
I don’t remember my parents ever discussing my diagnosis. Perhaps they were too shocked. My dad muttered chromosome about still being able to adopt, and didn’t return to the baby.